Author/Authors :
Chung، نويسنده , , Christine H and Parker، نويسنده , , Joel S and Karaca، نويسنده , , Gamze and Wu، نويسنده , , Junyuan and Funkhouser، نويسنده , , William K and Moore، نويسنده , , Dominic and Butterfoss، نويسنده , , Dale and Xiang، نويسنده , , Dong and Zanation، نويسنده , , Adam and Yin، نويسنده , , Xiaoying and Shockley، نويسنده , , William W and Weissler، نويسنده , , Mark C and Dressler، نويسنده , , Lynn G and Shores، نويسنده , , Carol G and Yarbrough، نويسنده , , Wendell G and Perou، نويسنده , , Charles M، نويسنده ,
Abstract :
The prognostication of head and neck squamous cell carcinoma (HNSCC) is largely based upon the tumor size and location and the presence of lymph node metastases. Here we show that gene expression patterns from 60 HNSCC samples assayed on cDNA microarrays allowed categorization of these tumors into four distinct subtypes. These subtypes showed statistically significant differences in recurrence-free survival and included a subtype with a possible EGFR-pathway signature, a mesenchymal-enriched subtype, a normal epithelium-like subtype, and a subtype with high levels of antioxidant enzymes. Supervised analyses to predict lymph node metastasis status were approximately 80% accurate when tumor subsite and pathological node status were considered simultaneously. This work represents an important step toward the identification of clinically significant biomarkers for HNSCC.
