Author/Authors :
Ma، نويسنده , , Xiao-Jun and Wang، نويسنده , , Zuncai and Ryan، نويسنده , , Paula D and Isakoff، نويسنده , , Steven J and Barmettler، نويسنده , , Anne and Fuller، نويسنده , , Andrew J. Muir، نويسنده , , Beth and Mohapatra، نويسنده , , Gayatry and Salunga، نويسنده , , Ranelle and Tuggle، نويسنده , , J.Todd and Tran، نويسنده , , Yen Hai Tran، نويسنده , , Diem and Tassin، نويسنده , , Ana and Amon، نويسنده , , Paul and Wang، نويسنده , , Wilson and Wang، نويسنده , , Wei and Enright، نويسنده , , Edward and Stecker، نويسنده , , Kimberly and Estepa-Sabal، نويسنده , , Eden and Smith، نويسنده , , Barbara A. Younger، نويسنده , , Jerry and Balis، نويسنده , , Ulysses and Michaelson، نويسنده , , James and Bhan، نويسنده , , Atul and Habin، نويسنده , , Karleen and Baer، نويسنده , , Thomas M and Brugge، نويسنده , , Joan and Haber، نويسنده , , Daniel A and Erlander، نويسنده , , Mark G and Sgroi، نويسنده , , Dennis C، نويسنده ,
Abstract :
Tamoxifen significantly reduces tumor recurrence in certain patients with early-stage estrogen receptor-positive breast cancer, but markers predictive of treatment failure have not been identified. Here, we generated gene expression profiles of hormone receptor-positive primary breast cancers in a set of 60 patients treated with adjuvant tamoxifen monotherapy. An expression signature predictive of disease-free survival was reduced to a two-gene ratio, HOXB13 versus IL17BR, which outperformed existing biomarkers. Ectopic expression of HOXB13 in MCF10A breast epithelial cells enhances motility and invasion in vitro, and its expression is increased in both preinvasive and invasive primary breast cancer. The HOXB13:IL17BR expression ratio may be useful for identifying patients appropriate for alternative therapeutic regimens in early-stage breast cancer.
