Author/Authors :
Wang، نويسنده , , Shao-Chun and Lien، نويسنده , , Huang-Chun and Xia، نويسنده , , Weiya and Chen، نويسنده , , I.-Fen and Lo، نويسنده , , Hui-Wen and Wang، نويسنده , , Zhiqin and Ali-Seyed، نويسنده , , Mohamed and Lee، نويسنده , , Dung-Fang and Bartholomeusz، نويسنده , , Geoffrey and Ou-Yang، نويسنده , , Fu and Giri، نويسنده , , Dipak K. and Hung، نويسنده , , Mien-Chie، نويسنده ,
Abstract :
Pathological expression of human ErbB-2 protein, also known as HER-2, is common in many types of cancer. ErbB-2 is a member of the EGF receptor tyrosine kinase family and has been rigorously studied as a signaling molecule on the cell membrane. Here, we report that ErbB-2 is also expressed in the nucleus in cultured cells as well as primary tumor tissues. Nuclear ErbB-2 was found to associate with multiple genomic targets in vivo, including the cyclooxygenase enzyme COX-2 gene promoter. ErbB-2 forms a complex at a specific nucleotide sequence of the COX-2 promoter and is able to stimulate its transcription. This study demonstrates the presence of ErbB-2 in the nucleus and identifies the function of ErbB-2 as a transcriptional regulator.
