Title of article :
The Morphogenetic Code and Colon Cancer Development
Author/Authors :
van den Brink، نويسنده , , Gijs R. and Offerhaus، نويسنده , , G. Johan، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2007
Pages :
9
From page :
109
To page :
117
Abstract :
The initiating genetic lesion in sporadically occurring cancers is impossible to identify. The existence of rare inherited cancer syndromes has helped to uncover some of the mutations that can initiate tumorigenesis. Most of these initiating lesions affect genes belonging to morphogenetic signaling pathways. We review the evidence that the cellular fate of individual epithelial cells in the adult is nonautonomous and depends on extrinsic information, just like cells in a developing embryo. Cancer stem cells need to disrupt these extrinsic restraints to gain an autonomous clonal proliferative advantage over neighboring stem cells.
Journal title :
Cancer Cell
Serial Year :
2007
Journal title :
Cancer Cell
Record number :
1336416
Link To Document :
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