Author/Authors :
Jongsma، نويسنده , , Johan and van Montfort، نويسنده , , Erwin and Vooijs، نويسنده , , Marc and Zevenhoven، نويسنده , , John and Krimpenfort، نويسنده , , Paul and van der Valk، نويسنده , , Martin and van de Vijver، نويسنده , , Marc and Berns، نويسنده , , Anton، نويسنده ,
Abstract :
Summary
ant mesothelioma is a devastating disease that has been associated with loss of Neurofibromatosis type 2 (NF2) and genetic lesions affecting RB and P53 pathways. We introduced similar lesions in the mesothelial lining of the thoracic cavity of mice. Mesothelioma developed at high incidence in Nf2;Ink4a/Arf and Nf2;p53 conditional knockout mice with median survival times of approximately 30 and 20 weeks, respectively. Murine mesothelioma closely mimicked human malignant mesothelioma. Conditional Nf2;Ink4a/Arf mice showed increased pleural invasion compared to conditional Nf2;p53 mice. Interestingly, upon Ink4a loss in the latter mice median survival was significantly reduced and all tumors were highly invasive, suggesting that Ink4a loss substantially contributes to the poor clinical outcome of malignant mesothelioma.
