Inflamed Snail Speeds Metastasis

Macrophage infiltration and inflammatory cytokines are powerful drivers of tumorigenesis and metastasis. Wu et al., in this issue of Cancer Cell, show that TNFα-dependent NFκB activation induces COP9 signalosome-mediated inhibition of GSK3β and the SCFβ-TRCP ubiquitin ligase, thus leading to stabilization of the transcription factor Snail and promoting cell migration and metastasis.