Title of article :
Expression of Autotaxin and Lysophosphatidic Acid Receptors Increases Mammary Tumorigenesis, Invasion, and Metastases
Author/Authors :
Liu، نويسنده , , Shuying and Umezu-Goto، نويسنده , , Makiko and Murph، نويسنده , , Mandi and Lu، نويسنده , , Yiling and Liu، نويسنده , , Wenbin and Zhang، نويسنده , , Fan and Yu، نويسنده , , Shuangxing and Stephens، نويسنده , , L. Clifton and Cui، نويسنده , , Xiaojiang and Murrow، نويسنده , , George and Coombes، نويسنده , , Kevin and Muller، نويسنده , , William N.N. Hung، نويسنده , , Mien-Chie and Perou، نويسنده , , Charles M. C. Lee، نويسنده , , Adrian V. and Fang، نويسنده , , Xianjun and Mills، نويسنده , , Gordon B.، نويسنده ,
Abstract :
Summary
osphatidic acid (LPA) acts through high-affinity G protein-coupled receptors to mediate a plethora of physiological and pathological activities associated with tumorigenesis. LPA receptors and autotaxin (ATX/LysoPLD), the primary enzyme producing LPA, are aberrantly expressed in multiple cancer lineages. However, the role of ATX and LPA receptors in the initiation and progression of breast cancer has not been evaluated. We demonstrate that expression of ATX or each edg family LPA receptor in mammary epithelium of transgenic mice is sufficient to induce a high frequency of late-onset, estrogen receptor (ER)-positive, invasive, and metastatic mammary cancer. Thus, ATX and LPA receptors can contribute to the initiation and progression of breast cancer.
