Discovery of Novel Transcriptional and Epigenetic Targets in APL by Global ChIP Analyses: Emerging Opportunity and Challenge

Identifying transcriptional program(s) deregulated by oncoproteins is key to understanding the molecular basis of the disease. In this issue of Cancer Cell, two studies by Martens et al. and Wang et al. provide global blueprints for transcriptional targets and epigenetic modifications mediated by PML-RARα in acute promyelocytic leukemia.