Tumor Vessels Are Eph-ing Complicated

Two new studies have shown that there is considerable crosstalk and cross-regulation of the Ephrin/VEGF pathways in endothelial cells. These findings illustrate how EphrinB2 signaling and VEGF, in a cooperative manner, induce VEGFR activation in endothelial cells and give new insight into how endothelial cell-mediated construction of vessels is accomplished.