The Molecular Biology of Myeloproliferative Disorders

The myeloproliferative disorders (MPDs) are a spectrum of clonal disorders of the hematopoietic system. The discovery of activating mutations of the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and primary myelofibrosis has lead to in vitro and animal model studies that promise to lead to therapeutic advances.