Author/Authors :
Goh، نويسنده , , Amanda M. and Lane، نويسنده , , David P.، نويسنده ,
Abstract :
Excitement and controversy followed the discovery that a frequently occurring single nucleotide polymorphism in noncoding DNA affects cancer susceptibility. In this issue of Cancer Cell, Post et al. (2010) report using a mouse model to demonstrate directly that this subtle genetic variation significantly attenuates the p53 pathway and accelerates tumor formation.
