BLIMP1 against Lymphoma: The Verdict Is Reached

BLIMP1, a master regulator of plasma-cell differentiation, is implicated in the pathogenesis of Activated B cell (ABC)-like Diffuse Large B cell Lymphoma (DLBCL). In this issue of Cancer Cell, Mandelbaum and colleagues and Calado and colleagues unequivocally demonstrate that BLIMP1 functions as a tumor suppressor and guardian of ABC-like DLBCL lymphomagenesis.