Title of article
Non-Stem Cell Origin for Oligodendroglioma
Author/Authors
Persson، نويسنده , , Anders I. and Petritsch، نويسنده , , Claudia and Swartling، نويسنده , , Fredrik J. and Itsara، نويسنده , , Melissa and Sim، نويسنده , , Fraser J. and Auvergne، نويسنده , , Romane and Goldenberg، نويسنده , , David D. and Vandenberg، نويسنده , , Scott R. and Nguyen، نويسنده , , Kim N. and Yakovenko، نويسنده , , Stanislava and Ayers-Ringler، نويسنده , , Jennifer and Nishiyama، نويسنده , , Akiko and Stallcup، نويسنده , , William B. and Berger، نويسنده , , Mitchel S. and Bergers، نويسنده , , Gabriele and McKnight، نويسنده , , Tracy R. and Goldman، نويسنده , , Steven A. and Weiss، نويسنده , , William A.، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2010
Pages
14
From page
669
To page
682
Abstract
Summary
ant astrocytic brain tumors are among the most lethal cancers. Quiescent and therapy-resistant neural stem cell (NSC)-like cells in astrocytomas are likely to contribute to poor outcome. Malignant oligodendroglial brain tumors, in contrast, are therapy sensitive. Using magnetic resonance imaging (MRI) and detailed developmental analyses, we demonstrated that murine oligodendroglioma cells show characteristics of oligodendrocyte progenitor cells (OPCs) and are therapy sensitive, and that OPC rather than NSC markers enriched for tumor formation. MRI of human oligodendroglioma also suggested a white matter (WM) origin, with markers for OPCs rather than NSCs similarly enriching for tumor formation. Our results suggest that oligodendroglioma cells show hallmarks of OPCs, and that a progenitor rather than a NSC origin underlies improved prognosis in patients with this tumor.
Journal title
Cancer Cell
Serial Year
2010
Journal title
Cancer Cell
Record number
1337340
Link To Document