Title of article
Metastatic Colon Cancer Cells Negotiate the Intravasation Notch
Author/Authors
Christofori، نويسنده , , Gerhard، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2011
Pages
3
From page
6
To page
8
Abstract
In this issue of Cancer Cell, Sonoshita et al. report that Aes/Grg5 prevents metastasis of colorectal cancer cells by sequestering and inactivating Notch transcriptional effectors in distinct nuclear foci. Loss of Aes/Grg5 in invasive cancer cells where Notch is activated by stroma-expressed ligands promotes invasion, transendothelial migration, intravasation, and metastasis.
Journal title
Cancer Cell
Serial Year
2011
Journal title
Cancer Cell
Record number
1337355
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