Author/Authors :
Hua، نويسنده , , Kuo-Tai and Tan، نويسنده , , Ching-Ting and Johansson، نويسنده , , Gunnar and Lee، نويسنده , , Jang-Ming and Yang، نويسنده , , Pei-Wen and Lu، نويسنده , , Hsin-Yi and Chen، نويسنده , , Chi-Kuan and Su، نويسنده , , Jen-Liang and Chen، نويسنده , , PoShen B. and Wu، نويسنده , , Yu-Ling and Chi، نويسنده , , Chia-Chun and Kao، نويسنده , , Hsin-Jung and Shih، نويسنده , , Hou-Jung and Chen، نويسنده , , Min-Wei and Chien، نويسنده , , Ming-Hsien and Chen، نويسنده , , Pai-Sheng and Lee، نويسنده , , Wei-Jiunn and Cheng، نويسنده , , Tsu-Yao and Rosenberger، نويسنده , , George and Chai، نويسنده , , Chee-Yin and Yang، نويسنده , , Chih-Jen and Huang، نويسنده , , Ming-Shyan and Lai، نويسنده , , Tsung-Ching and Chou، نويسنده , , Teh-Ying and Hsiao، نويسنده , , Michael and Kuo، نويسنده , , Min-Liang، نويسنده ,
Abstract :
Summary
etyltransferase 10 protein, Naa10p, is an N-acetyltransferase known to be involved in cell cycle control. We found that Naa10p was expressed lower in varieties of malignancies with lymph node metastasis compared with non-lymph node metastasis. Higher Naa10p expression correlates the survival of lung cancer patients. Naa10p significantly suppressed migration, tumor growth, and metastasis independent of its enzymatic activity. Instead, Naa10p binds to the GIT-binding domain of PIX, thereby preventing the formation of the GIT-PIX-Paxillin complex, resulting in reduced intrinsic Cdc42/Rac1 activity and decreased cell migration. Forced expression of PIX in Naa10-transfected tumor cells restored the migration and metastasis ability. We suggest that Naa10p functions as a tumor metastasis suppressor by disrupting the migratory complex, PIX-GIT- Paxillin, in cancer cells.
