Author/Authors :
Homminga، نويسنده , , Irene and Pieters، نويسنده , , Rob and Langerak، نويسنده , , Anton W. and de Rooi، نويسنده , , Johan J. and Stubbs، نويسنده , , Andrew and Verstegen، نويسنده , , Monique and Vuerhard، نويسنده , , Maartje and Buijs-Gladdines، نويسنده , , Jessica and Kooi، نويسنده , , Clarissa and Klous، نويسنده , , Petra and van Vlierberghe، نويسنده , , Pieter and Ferrando، نويسنده , , Adolfo A. and Cayuela، نويسنده , , Jean Michel and Verhaaf، نويسنده , , Brenda and Beverloo، نويسنده , , H. Berna and Horstmann، نويسنده , , Martin and de Haas، نويسنده , , Valerie and Wiekmeijer، نويسنده , , Anna-Sophia and Pike-Overzet، نويسنده , , Karin and Staal، نويسنده , , Frank J.T. and de Laat، نويسنده , , Wouter and Soulier، نويسنده , , Jean and Sigaux، نويسنده , , Francois and Meijerink، نويسنده , , Jules P.P.، نويسنده ,
Abstract :
Summary
ntify oncogenic pathways in T cell acute lymphoblastic leukemia (T-ALL), we combined expression profiling of 117 pediatric patient samples and detailed molecular-cytogenetic analyses including the Chromosome Conformation Capture on Chip (4C) method. Two T-ALL subtypes were identified that lacked rearrangements of known oncogenes. One subtype associated with cortical arrest, expression of cell cycle genes, and ectopic NKX2-1 or NKX2-2 expression for which rearrangements were identified. The second subtype associated with immature T cell development and high expression of the MEF2C transcription factor as consequence of rearrangements of MEF2C, transcription factors that target MEF2C, or MEF2C-associated cofactors. We propose NKX2-1, NKX2-2, and MEF2C as T-ALL oncogenes that are activated by various rearrangements.
