BCL6: A Novel Target for Therapy of Ph+ B Cell Acute Lymphoblastic Leukemia

BCL6 is a zinc-finger transcriptional repressor known for its oncogenic role in B cell lymphoma. In a recent issue of Nature, Duy et al. describe a novel role for BCL6 at the center of a transcriptional network in Ph+ acute lymphoblastic leukemia cells that modulates their leukemogenicity and response to kinase inhibitors.