Author/Authors :
Gaziel-Sovran، نويسنده , , Avital and Segura، نويسنده , , Miguel F. and Di Micco، نويسنده , , Raffaella and Collins، نويسنده , , Mary K. and Hanniford، نويسنده , , Douglas and Vega-Saenz de Miera، نويسنده , , Eleazar and Rakus، نويسنده , , John F. and Dankert، نويسنده , , John F. and Shang، نويسنده , , Shulian and Kerbel، نويسنده , , Robert S. and Bhardwaj، نويسنده , , Nina and Shao، نويسنده , , Yongzhao and Darvishian، نويسنده , , Farbod and Zavadil، نويسنده , , Jiri and Erlebacher، نويسنده , , Adrian and Mahal، نويسنده , , Lara K. and Osman، نويسنده , , Iman and Hernando، نويسنده , , Eva، نويسنده ,
Abstract :
Summary
astasize, a tumor cell must acquire abilities such as the capacity to colonize new tissue and evade immune surveillance. Recent evidence suggests that microRNAs can promote the evolution of malignant behaviors by regulating multiple targets. We performed a microRNA analysis of human melanoma, a highly invasive cancer, and found that miR-30b/30d upregulation correlates with stage, metastatic potential, shorter time to recurrence, and reduced overall survival. Ectopic expression of miR-30b/30d promoted the metastatic behavior of melanoma cells by directly targeting the GalNAc transferase GALNT7, resulted in increased synthesis of the immunosuppressive cytokine IL-10, and reduced immune cell activation and recruitment. These data support a key role of miR-30b/30d and GalNAc transferases in metastasis, by simultaneously promoting cellular invasion and immunosuppression.