Title of article
DePICTing p53 Activation: A New Nucleolar Link to Cancer
Author/Authors
Golomb، نويسنده , , Lior and Oren، نويسنده , , Moshe، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2011
Pages
2
From page
283
To page
284
Abstract
p53 activation by ribosomal biogenesis stress is important for tumor suppression. In the August issue of Nature Medicine, Sasaki et al. identify PICT1 as a regulator of this process. PICT1 sequesters ribosomal protein RPL11 in the nucleolus, attenuating p53 induction. Excessive PICT1 may dampen the p53 response and promote cancer.
Journal title
Cancer Cell
Serial Year
2011
Journal title
Cancer Cell
Record number
1337608
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