Title of article :
DePICTing p53 Activation: A New Nucleolar Link to Cancer
Author/Authors :
Golomb، نويسنده , , Lior and Oren، نويسنده , , Moshe، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2011
Abstract :
p53 activation by ribosomal biogenesis stress is important for tumor suppression. In the August issue of Nature Medicine, Sasaki et al. identify PICT1 as a regulator of this process. PICT1 sequesters ribosomal protein RPL11 in the nucleolus, attenuating p53 induction. Excessive PICT1 may dampen the p53 response and promote cancer.
Journal title :
Cancer Cell
Journal title :
Cancer Cell
