Author/Authors :
Taguchi، نويسنده , , Ayumu and Politi، نويسنده , , Katerina and Pitteri، نويسنده , , Sharon J. and Lockwood، نويسنده , , William W. and Faça، نويسنده , , Vitor M. and Kelly-Spratt، نويسنده , , Karen J. Wong، نويسنده , , Chee-Hong and Zhang، نويسنده , , Qing and Chin، نويسنده , , Alice and Park، نويسنده , , Kwon-Sik and Goodman، نويسنده , , Gary and Gazdar، نويسنده , , Adi F. and Sage، نويسنده , , Julien and Dinulescu، نويسنده , , Daniela M. and Kucherlapati، نويسنده , , Raju and DePinho، نويسنده , , Ronald A. and Kemp، نويسنده , , Christopher J. and Varmus، نويسنده , , Harold E. and Hanash، نويسنده , , Samir M.، نويسنده ,
Abstract :
Summary
estigated the potential of in-depth quantitative proteomics to reveal plasma protein signatures that reflect lung tumor biology. We compared plasma protein profiles of four mouse models of lung cancer with profiles of models of pancreatic, ovarian, colon, prostate, and breast cancer and two models of inflammation. A protein signature for Titf1/Nkx2-1, a known lineage-survival oncogene in lung cancer, was found in plasmas of mouse models of lung adenocarcinoma. An EGFR signature was found in plasma of an EGFR mutant model, and a distinct plasma signature related to neuroendocrine development was uncovered in the small-cell lung cancer model. We demonstrate relevance to human lung cancer of the protein signatures identified on the basis of mouse models.
