• Title of article

    Resistance to EGFR-Targeted Therapy: A Family Affair

  • Author/Authors

    Vlacich، نويسنده , , Gregory and Coffey، نويسنده , , Robert J.، نويسنده ,

  • Issue Information
    روزنامه با شماره پیاپی سال 2011
  • Pages
    3
  • From page
    423
  • To page
    425
  • Abstract
    The EGFR-directed antibody cetuximab has proven, albeit modest, clinical benefit as monotherapy in head and neck and colorectal cancers. In a recent study, Yonesaka et al. uncovered a new mechanism of cetuximab resistance mediated by increased ERBB2 signaling via amplification of ERBB2 or increased levels of the ERBB3/ERBB4 ligand heregulin.
  • Journal title
    Cancer Cell
  • Serial Year
    2011
  • Journal title
    Cancer Cell
  • Record number

    1337650

    • Link To Document
    https://search.isc.ac/dl/search/defaultta.aspx?DTC=10&DC=1337650