Author/Authors :
Zeisig، نويسنده , , Bernd B. and Arteaga، نويسنده , , Mari-Francis and Thirant، نويسنده , , Cecile and So، نويسنده , , Chi Wai Eric، نويسنده ,
Abstract :
PcG and TrxG proteins mostly with opposite transcriptional activities play key roles in normal and malignant development. In this issue of Cancer Cell, Tan et al. report an unexpected collaboration between CBX8 and MLL-AF9 in leukemia, revealing a far more complicated functional crosstalk between these master epigenetic regulators in oncogenesis.
