Title of article
IL-10 Elicits IFNγ-Dependent Tumor Immune Surveillance
Author/Authors
Mumm، نويسنده , , John B. and Emmerich، نويسنده , , Jan and Zhang، نويسنده , , Xueqing and Chan، نويسنده , , Ivan and Wu، نويسنده , , Lingling and Mauze، نويسنده , , Smita and Blaisdell، نويسنده , , Steven and Basham، نويسنده , , Beth and Dai، نويسنده , , Jie and Grein، نويسنده , , Jeff and Sheppard، نويسنده , , Catherine and Hong، نويسنده , , Kyu and Cutler، نويسنده , , Collette and Turner، نويسنده , , Scott and LaFace، نويسنده , , Drake and Kleinschek، نويسنده , , Melanie and Judo، نويسنده , , Michael and Ayanoglu، نويسنده , , Gulesi and Langowski، نويسنده , , John and Gu، نويسنده , , Danling and Paporello، نويسنده , , Brittany and Murphy، نويسنده , , Erin and Sriram، نويسنده , , Venkataraman and Naravula، نويسنده , , Saraswathi and Desai، نويسنده , , Bela and Medicherla، نويسنده , , Satya and Seghezzi، نويسنده , , Wolfgang and McClanahan، نويسنده , , Terrill and Cannon-Carlson، نويسنده , , Susan and Beebe، نويسنده , , Amy M. and Oft، نويسنده , , Martin، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2011
Pages
16
From page
781
To page
796
Abstract
Summary
immune surveillance and cancer immunotherapies are thought to depend on the intratumoral infiltration of activated CD8+ T cells. Intratumoral CD8+ T cells are rare and lack activity. IL-10 is thought to contribute to the underlying immune suppressive microenvironment. Defying those expectations we demonstrate that IL-10 induces several essential mechanisms for effective antitumor immune surveillance: infiltration and activation of intratumoral tumor-specific cytotoxic CD8+ T cells, expression of the Th1 cytokine interferon-γ (IFNγ) and granzymes in CD8+ T cells, and intratumoral antigen presentation molecules. Consequently, tumor immune surveillance is weakened in mice deficient for IL-10 whereas transgenic overexpression of IL-10 protects mice from carcinogenesis. Treatment with pegylated IL-10 restores tumor-specific intratumoral CD8+ T cell function and controls tumor growth.
Journal title
Cancer Cell
Serial Year
2011
Journal title
Cancer Cell
Record number
1337739
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