Title of article :
How to Fool a Wonder Drug: Truncate and Dimerize
Author/Authors :
Molina-Arcas، نويسنده , , Miriam and Downward، نويسنده , , Julian، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2012
Abstract :
In a recent paper, Poulikakos et al. describe a new and potentially common mechanism whereby melanomas develop resistance to the BRAF inhibitor vemurafenib by expressing truncated forms of BRAF(V600E) that can dimerize in the absence of activated RAS. Will it be possible to block this with improved BRAF inhibitor design?
Journal title :
Cancer Cell
Journal title :
Cancer Cell
