Author/Authors :
Cooke، نويسنده , , Vesselina G. and LeBleu، نويسنده , , Valerie S. and Keskin، نويسنده , , Doruk and Khan، نويسنده , , Zainab and OʹConnell، نويسنده , , Joyce T. and Teng، نويسنده , , Yingqi and Duncan، نويسنده , , Michael B. and Xie، نويسنده , , Liang and Maeda، نويسنده , , Genta and Vong، نويسنده , , Sylvia and Sugimoto، نويسنده , , Hikaru and Rocha، نويسنده , , Rafael M. and Damascena، نويسنده , , Aline and Brentani، نويسنده , , Ricardo R. and Kalluri، نويسنده , , Raghu، نويسنده ,
Abstract :
Summary
nctional role of pericytes in cancer progression remains unknown. Clinical studies suggest that low numbers of vessel-associated pericytes correlated with a drop in overall survival of patients with invasive breast cancer. Using genetic mouse models or pharmacological inhibitors, pericyte depletion suppressed tumor growth but enhanced metastasis. Pericyte depletion was further associated with increased hypoxia, epithelial-to-mesenchymal transition (EMT), and Met receptor activation. Silencing of Twist or use of a Met inhibitor suppressed hypoxia and EMT/Met-driven metastasis. In addition, poor pericyte coverage coupled with high Met expression in cancer cells speculates the worst prognosis for patients with invasive breast cancer. Collectively, our study suggests that pericytes within the primary tumor microenvironment likely serve as important gatekeepers against cancer progression and metastasis.
