Author/Authors :
Workman، نويسنده , , Paul and Clarke، نويسنده , , Paul A. and Al-Lazikani، نويسنده , , Bissan، نويسنده ,
Abstract :
Two recent papers published in Nature demonstrate the power of systematic high-throughput pharmacologic profiling of very large, diverse, molecularly-characterized human cancer cell line panels to reveal linkages between genetic profile and targeted-drug sensitivity. Known oncogene addictions are confirmed while surprising complexities and biomarker relationships with clinical potential are revealed.
