• Title of article

    IDH1 Mutations Disrupt Blood, Brain, and Barriers

  • Author/Authors

    Shih، نويسنده , , Alan H. and Levine، نويسنده , , Ross L.، نويسنده ,

  • Issue Information
    روزنامه با شماره پیاپی سال 2012
  • Pages
    3
  • From page
    285
  • To page
    287
  • Abstract
    The first two murine models of IDH1(R132H) mutation provide mechanistic insights into transformation. In hematopoietic cells, inhibition of TET2 and histone demethylases leads to epigenetic alterations and accumulation of hematopoietic precursors. In the central nervous system, inhibition of collagen and prolyl hydroxylases lead to altered microenvironment and defective angiogenesis.
  • Journal title
    Cancer Cell
  • Serial Year
    2012
  • Journal title
    Cancer Cell
  • Record number

    1338004

    • Link To Document
    https://search.isc.ac/dl/search/defaultta.aspx?DTC=10&DC=1338004