Author/Authors :
Kadivar، Maryam نويسنده Department of Pathology, Hazrate- Rasoul Akram Hospital, Iran University of Medical Sciences, TEHRAN-IRAN. , , Babaheidarian، Pegah نويسنده Dept. of Pathology, Tehran University of Medical Sciences, Tehran , , Zare Mirzae، Ali نويسنده Dept. of Pathology, Tehran University of Medical Sciences, Tehran , , Fakhraie، Mohammadreza نويسنده Surgery Ward, Atieh Hospital, Tehran ,
Abstract :
There are few reported cases of endobronchial metastasis of pheochromocytoma in pathology
literature. We present here a 56-year old woman who underwent left lower lobectomy of lung,
following pneumonia with unresolved chest radiographs. Computed tomography showed a lobulated
soft tissue mass, measuring, 38×27 mm, at the perivascular space of anterior mediastinum. The
resected specimen, showed lobulated tumor arranged in nesting pattern within arcuate vascular
network. Immunohistochemistry showed intense positive staining of epitheloid cell (chief cells) for
chromogranin and synaptophysin which were negative for cytokeratin. Sustentacular cells were
strongly positive for S-100. Although very rare, physicians should keep in mind the possibility of
endobronchial metastasis in patients with a history of pheochromocytoma.
