Author/Authors :
Vosooghi، M. نويسنده , , Rajabalian، S. نويسنده Kerman Neuroscience Research Center, Kerman University of Medical Sciences, Kerman, I.R.Iran. , , Sorkhi، M. نويسنده , , Badinloo، M. نويسنده Kerman Physiology Research Center, Kerman University of Medical Sciences, Kerman, I.R.Iran. , , Nakhjiri، M. نويسنده Drug Design & Development Research Center, Tehran University of Medical Sciences, Tehran, I.R.Iran. , , Negahbani، A.S. نويسنده Drug Design & Development Research Center, Tehran University of Medical Sciences, Tehran, I.R.Iran. , , Asadipour، A. نويسنده Kerman Neuroscience Research Center, Kerman University of Medical Sciences, Kerman, I.R.Iran. , , Mahdavi، M. نويسنده Institute of Biochemistry & Biophysics, University of Tehran, Tehran, I.R.Iran. , , Shafiee، A. نويسنده , , Foroumadi، A. نويسنده Department of Medicinal Chemistry, Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, I.R.Iran. ,
Abstract :
A series of 2-amino-4-aryl-3-cyano-7-(dimethylamino)-4H-chromenes was synthesized by condensation of 3-(dimethylamino)phenol, an aromatic aldehyde and malonitrile in ethanol containing piperidine. The assignments of the structure of all synthesized compounds were based on spectral data (IR, Mass and 1H NMR). The cytotoxic activities of the synthesized compounds against six human tumor cell lines were determined by MTT assay. Several compounds showed significant cytotoxic activity.
