Comparison of Efficacy of Two Dose Rates of Histrelin for Inducing Ovulation in Broodmares

Between February 14 and April 26, 2012, 75 broodmares (7 maiden, 11 barren, and 57 foaling) maintained on pasture in southeast Texas were examined three times weekly (Tuesday, Thursday, Saturday) by transrectal palpation and ultrasonography. On Tuesday or Thursday, mares in estrus with uterine edema, a relaxed cervix, and a dominant follicle ≥30-mm diameter were alternately assigned to treatment with 0.5 mg of intramuscular (IM) histrelin (group 1) or 0.25 mg IM histrelin (group 2). Ovulation was confirmed by ultrasound examination. No differences in proportion of maiden plus barren (96%) compared to foaling (86%) mares ovulating within 2 days was found (P > .10); therefore, responses for all mares were combined for analysis. No differences in ovulation rates within 2 days were noted for 0.5 mg histrelin compared to those for 0.25 mg histrelin treatment (42 of 46, 91%; 44 of 52, 85%; P > .10). No differences were detected between response rates to 0.5 or to 0.25 mg histrelin for any month (P > .10). The use of 0.5 or 0.25 mg histrelin were found to be effective treatments for inducing ovulation within 2 days of administration throughout the early breeding season.