Author/Authors :
Khan، Taseer Ahmed نويسنده Poultry Research Unit, Department of Physiology, University of Karachi-75270, Pakistan Khan, Taseer Ahmed , Khan، Muhammad Noman نويسنده Poultry Research Unit, Department of Physiology, University of Karachi-75270, Pakistan Khan, Muhammad Noman , Hasan، Ruqaiya نويسنده Hematology Unit, Department of Physiology, University of Karachi-75270, Pakistan Hasan, Ruqaiya , Fatima، Habib نويسنده Hematology Unit, Department of Physiology, University of Karachi-75270, Pakistan Fatima, Habib , Kousar، Einas نويسنده Hematology Unit, Department of Physiology, University of Karachi-75270, Pakistan Kousar, Einas
Abstract :
Acetaminophen is an analgesic and antipyretic agent administered in high doses causes kidney and liver necrosis both in humans and in animals. Nigella sativa (Black seed) has been reported to have hepatoprotective and nephroprotective properties. Present investigation is performed to find out the effects of aqueous solution of Nigella sativa and its oil extract on serum urea and uric acid levels of layer chicks after oral administration of a single dose of 300 mg acetaminophen/kg body weight. Observations indicated that oral administration of acetaminophen to layer chicks caused significant (p < 0.05) decrease in mean serum urea while non-significant decrease in mean serum uric acid concentration. The results of this study indicated that Nigella sativa has positive effects on urea and uric acid concentrations during the administration of acetaminophen overdose. However, Nigella sativa oil extract is more effective than its aqueous solution.
