Development of a hollow fiber membrane module for using implantable artificial lung

This study examined the effects of multiple mechanical forces on gas exchange and hemolysis in intravascular lung assist devices (IVLAD). Specific attention was paid to on the effect of membrane vibration. This study adhered to the recommended practice for the assessment of hemolysis described by the American Society of Testing and Materials (ASTM). The results showed a higher oxygen (O2) transfer rate and carbon dioxide (CO2) removal rate in each excited frequency bandwidth than those without vibration. The maximum oxygen transfer and carbon dioxide removal rate occurred at frequency band of 7 Hz. The gas exchange improved maximum 52%. The plasma-free hemoglobin was 11.2 ± 0.57 and 14.4 ± 0.74 mg/100 ml by exciting a piezo-vibrator with a sinusoidal wave magnitude of DC10 V and DC50 V, respectively. The NIHO value was determined to be 59 ± 2.76 and 95 ± 4.32 mg/100 ml by exciting a piezo-vibrator with a sinusoidal wave magnitude of DC10 V and DC50 V, respectively. In conclusion, piezoelectric lead zirconate titanate (PZT) materials are exciting systems for improving the oxygen transfer efficiency and blood suitability of hollow fiber membrane in the development of new IVLAD.