Author/Authors :
Khadem Haghighian، Mahdieh نويسنده Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran , , Alipoor، Beitollah نويسنده School of Nutrition, Tabriz University of Medical Sciences, Tabriz, Iran , , Eftekhar Sadat، Bina نويسنده Physical Medicine and Rehabilitation Research Center, Tabriz University of Medical Sciences, Tabriz, Iran , , Malek Mahdavi، Aida نويسنده School of Nutrition, Tabriz University of Medical Sciences, Tabriz, Iran , , Moghaddam، Abdolvahab نويسنده Department of Physical Medicine and Rehabilitation, Tabriz University of Medical Sciences, Tabriz, Iran , , Vatankhah، Amir-Mansour نويسنده Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran ,
Abstract :
Background: This study was designed to assess the effect of sesame seed on lipid profile and oxidative stress biomarkers in knee osteoarthritis (OA) patients.
Methods: Fifty patients with knee OA were allocated into two groups receiving 40 g of sesame seed daily along with standard medical therapy (n=25) or standard treatment (n=25) for two months. Serum total antioxidant capacity, malondialdehyde (MDA) and lipid profile (total cholesterol (TC), HDL-cholesterol, LDL-cholesterol, triglycerides) were measured.
Results: After the intervention period two months of study, serum TC, LDL-cholesterol and MDA decreased significantly in the sesame group (P < 0.05), while no significant difference in serum values of lipid profile and oxidative stress parameters was seen in the control group (P > 0.05). There was no signifi-cant difference in pre and post-treatment values of lipid profile and oxidative parameters between the two groups (P > 0.05).
Conclusion: Current study showed a positive effect of sesame seed in improving lipid profile and oxidative stress in patients with knee OA and indicated the fact that sesame seed might be of help to reduce oxidative stress in OA patients.
