In-Vitro Antibacterial Properties of Sage (Salvia officinalis) Ethanol Extract against Multidrug Resistant Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa and Klebsiella pneumoniae

Mosafa، Elham نويسنده Department of Microbiology, Islamic Azad University, Falavarjan Branch, Isfahan, Iran Mosafa, Elham , Yahyaabadi، Sima نويسنده Department of Biology, Falavarjan Branch, Islamic Azad University, Isfahan, Iran Yahyaabadi, Sima , Doudi، Monir نويسنده Department of Microbiology, Falavarjan Branch, Islamic Azad University, Isfahan, Iran Doudi, Monir

فصلنامه با شماره پیاپی 0 سال 2014

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Background: Due to excessive consumption of synthetic drugs, drug resistance rate of pathogenic bacteria is increasing and the need to find new compounds is necessary. The aim of this study was to investigate the antibacterial effect of ethanol extract of, sage to the four species of common pathogenic bacteria resistant to multiple drugs in vitro such as: Staphylococcus aureus (50 strains), Escherichia coli (50 strains), Pseudomonas aeruginosa (50 strains) and Klebsiella pneumonia (50 strains). Materials and Methods: In this experimental study, antibacterial effect of ethanol extract of sage plants on the development of multi-drug resistant bacteria was performed by well diffusion at concentrations of 50, 400, 100 mg/mLand microdilution method. Results: Ethanol extracts of sage in well diffusion method showed significant inhibitory effect on the growth of isolated bacteria. The results indicate the inhibitory effects of ethanol extract of sage with MIC (Minimum Inhibitory Concentration)=18.75 mg/mL for S. aureus, MIC=26.56 mg/mL for E. coli, MIC=33.75 mg/mL for P. aeruginosa and with MIC=31.25 mg/mL for K. pneumoniae. Conclusion: In relation with the antibacterial effect of ethanol extracts of Sage on the multi-drug resistant bacteria the use of herbs as an alternative to antibiotics after pharmacological studies, for treatment recommended.

Zahedan Journal of Research in Medical Sciences

2014

Zahedan Journal of Research in Medical Sciences

1362203