Author/Authors :
ghammami، shahriar نويسنده Department of Chemistry, Faculty of Science, Imam Khomeini International University, 34149-16818 Ghazvin, Iran ghammami, shahriar , Mohammadi، Mohammad Kazem نويسنده , , Amini، Zahra نويسنده former MSc student and associate professor, Department of Plant breeding, Faculty of Agriculture, Shahrekord University, Shahrekord , , Mirrahimi، Monir Al-sadat Mirrahimi نويسنده Department of Chemistry, Faculty of Science, Imam Khomeini International University, Ghazvin, Iran Mirrahimi, Monir Al-sadat Mirrahimi , Soleimani، Masoud نويسنده , , Kaviani، Saeid نويسنده ,
Abstract :
In this research, some of the inorganic complexes of uranyl with N- donor ligands were synthesized. Complexes were characteriezed by FT-IR and UV spectra, ¹HNMR, ¹³CNMR and some physical properties. The uranyl unit (UO2) is composed of a center of uranium atom with the charge (+6) and two oxygen atom by forming two U=O double bonds. The structure is linear (O=U=O, 180) and usually stable. So other ligands often coordinate to the U atom in the plane perpendicularly to the O=U=O axis. The antitumor activity of some of ligand and their complexes against a panel of human tumor cell lines (HT29: Haman colon adenocarcinoma cell line T47D: human breast adenocarcinoma cell line) were determined by MTT(3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl-tetrazolium bromide) assay. These data suggest that some of these compounds provide good models for the further design of potent antitumor compounds.
