Title of article
Cytotoxic activities of selected medicinal plants from Iran and phytochemical evaluation of the most potent extract
Author/Authors
Sahranavard، S. نويسنده Department of Pharmacognosy, School of Pharmacy, Shaheed Beheshti University of Medical Sciences, Tehran, I.R.Iran. , , Naghibi، F. نويسنده , , Mosaddegh، M. نويسنده Department of Traditional Pharmacy, School of Traditional Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran , , Esmaeili، S. نويسنده Department of Pharmacognosy, School of Pharmacy, Shaheed Beheshti University of Medical Sciences, Tehran, I.R.Iran. , , Sarkhail، P. نويسنده Traditional Medicine & Materia Medica Research Center, Shaheed Beheshti University of Medical Sciences, Tehran, I.R.Iran. , , Taghvaei، M. نويسنده Traditional Medicine & Materia Medica Research Center, Shaheed Beheshti University of Medical Sciences, Tehran, I.R.Iran. , , Ghafari، S. نويسنده Traditional Medicine & Materia Medica Research Center, Shaheed Beheshti University of Medical Sciences, Tehran, I.R.Iran. ,
Issue Information
دوفصلنامه با شماره پیاپی 0 سال 2009
Pages
5
From page
133
To page
137
Abstract
Methanolic extract of 15 Iranian medicinal plants were prepared and tested for their cytotoxic activities against three cancer cell lines (MCF7, HepG2, WEHI164) and one normal cell line (MDBK). Some plants showed cytotoxic activities. The extract of Ferula szowitsiana root, which proved to be the most active, was chosen for further phytochemical studies. The major compounds of the most potent acetone extract were isolated. They were identified as chimgin and chimganin, two known monoterpenoids, by spectroscopic means. Their cytotoxic activity was evaluated in three cell lines. The results show that these compounds are responsible, at least in part, for the cytotoxic activity of this plant.
Journal title
Research in Pharmaceutical Sciences
Serial Year
2009
Journal title
Research in Pharmaceutical Sciences
Record number
1367320
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