A One-Pot Synthesis of 1,8- Dioxodecahydroacridine Using Zinc Chloride Silica gel-supported Catalyst under Solvent-Free Conditions

Zinc chloride silica gel-supported was found to be an efficient, inexpensive catalyst for the synthesis of 1,8-dioxodecahydroacridines via one-pot three-component condensation of aryl aldehydes, dimedone, andammonium acetate in high yields. The described novel synthetic method propose several advantages of safety, mild condition, short reaction times, high yields, simplicityand easy workup compared to the traditional method of synthesis.