Tetrafluoro-4-pyridyl substituted cyclopentadienyl molybdenum(II) compounds

The allyl molybdenum(II) complex bearing tetrafluoro-4-pyridyl substituted cyclopentadienyl ligand, [(η3-C3H5){η5-C5H3(C5F4N)}Mo(CO)2], was synthesized and characterized by analytical and spectroscopic methods. This compound was found to be suitable precursor for complexes of the type [{η5-C5H4(C5F4N)}Mo(CO)2(NNL)][BF4] where NNL is N,N-chelating ligand. The biological study has shown that these complexes are cytotoxic active toward human leukemia cells MOLT-4. The cytotoxicity strongly depends on nature of the coordinated N,N-chelating ligand. The compounds bearing 1,10-phenanthroline (phen) and 2,2′-biquinoline (bq) are only medium active while the complexes with 4,7-diphenyl-1,10-phenanthroline (4,7-Ph2-phen) and 5-amino-1,10-phenanthroline (5-NH2-phen) show considerably higher activity than cisplatin. This study further describe the X-ray structures of [(η3-C3H5){η5-C5H4(C5F4N)}Mo(CO)2], [(η3-C3H5){η5-C5H3(1,3-C5F4N)2}Mo(CO)2], [{η5-C5H4(C5F4N)}Mo(CO)2(phen)][BF4] and [{η5-C5H4(C5F4N)}Mo(CO)2(5-NH2-phen)][BF4].