Synthesis of dioxazaborocines from N,N′-alkylbridged-bis(bis(2-hydroxybenzyl)aminomethyl)amines

The aminoalkylation of 2H-1,3-naphthoxazines by phenols has been used to prepare some tripodal amines. A series of these ligands were coordinated to boron, giving dioxazaborocines. The X-ray crystal structures of two dioxazaborocines are reported. These compounds are capable of releasing borate ions in vivo and are therefore potentially biologically active.