Author/Authors :
Atashafrooz، Zahra نويسنده Department of Chemistry, Urmia Payamnoor University, Urmia, Iran , , Maleki Dizaj، Solmaz نويسنده Student Research Committee, Tabriz University of Medical Science, Tabriz, Iran , , Salehi Sadaghiani، Alireza نويسنده Department of Chemistry, Urmia Payamnoor University, Urmia, Iran ,
Abstract :
Objective(s): Investigation of phase diagram of various drug formulations is effective to
predict different phase region of drugs to detect final formula. The purpose of this research
was to develop the ternary phase diagrams for a drug microemulsion system consisting of
Cucurbita pepo (pumpkin) oil, surfactant (Tween 80) and deionized water.
Materials and Methods: An electrical conductivity was used to study the properties of
system. Particle size analysis of microemulsion system was performed by dynamic light
scattering.
Results: The electrical conductivity of the microemulsions increases with increasing of
aqueous phase content. Structural transitions from the oil-in-water to a bi-continuous phase
then inversion to water-in-oil occured in the system. Diameter of particles was calculated 70
nm (for 75 percent of particles) and 35 nm (for 25 percent of particles). Solubility results
showed that microemulsion system of Cucurbita pepo oil can increase its solubility in
aqueous medium due to droplet size reduction into nanometer size.
Conclusion: Microemulsion technique can be used as a successful method in preparation of
Cucurbita pepo oil drug formulation
