Title of article
Development of a DNA-damaging ferrocene amino acid
Author/Authors
Daniel C. Cooper، نويسنده , , Craig J. Yennie، نويسنده , , Jesse B. Morin، نويسنده , , Sarah Delaney، نويسنده , , J. William Suggs، نويسنده ,
Issue Information
دوفصلنامه با شماره پیاپی سال 2011
Pages
4
From page
3058
To page
3061
Abstract
The oxygen-sensitive ferrocenylacetic acid moiety was incorporated in a water-soluble DNA-damaging agent via the synthon 1,1′-ferrocenediacetic acid anhydride. The extent of plasmid nicking was pH-dependent, with complete cleavage at pH 5.5. The nicking was indiscriminate and required O2, implicating reduced oxygen species as the actual damaging agent.
Keywords
Ferrocene , Proton coupled electron transfer , DNA damage , Nuclease
Journal title
Journal of Organometallic Chemistry
Serial Year
2011
Journal title
Journal of Organometallic Chemistry
Record number
1373159
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