Title of article
Synthesis and anticancer properties of gold(I) and silver(I) N-heterocyclic carbene complexes
Author/Authors
Tammy J. Siciliano، نويسنده , , Michael C. Deblock، نويسنده , , Khadijah M. Hindi، نويسنده , , Semih Durmus، نويسنده , , Matthew J. Panzner، نويسنده , , Claire A. Tessier، نويسنده , , Wiley J. Youngs، نويسنده ,
Issue Information
دوفصلنامه با شماره پیاپی سال 2011
Pages
6
From page
1066
To page
1071
Abstract
Bis(1,3-dimethylimidazol-2-ylidene)silver(I) nitrate and bis(4,5-dichloro-1,3-dimethylimidazol-2-ylidene)silver(I) nitrate were prepared by reacting the corresponding imidazolium nitrate salts with silver oxide. Bis(1,3-dimethylimidazol-2-ylidene)gold(I) nitrate and bis(4,5-dichloro-1,3-dimethylimidazol-2-ylidene)gold(I) nitrate salts were prepared via transmetallation of their silver precursors with chloro dimethylsulfide gold. The anticancer properties were determined using NCI-H460 lung cancer cells. Efficacy was established by comparison of the gold and silver compounds with cisplatin.
Keywords
Gold , N-heterocyclic carbene , Silver , Anticancer agent , Transmetallation
Journal title
Journal of Organometallic Chemistry
Serial Year
2011
Journal title
Journal of Organometallic Chemistry
Record number
1373705
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