Pyridylsilyl group-driven cross-coupling reactions

Summarized herein are the demonstrations that the use of 2-PyMe2Si group as a removable directing group is a powerful strategy for enhancing the efficiency of otherwise sluggish processes and for steering the course of the reaction by taking advantage of attractive substrate–catalyst interaction in the palladium-catalyzed cross-coupling chemistry. The 2-PyMe2Si group-driven Heck-type coupling, Hiyama-type coupling, Stille-type coupling, and allylic alkylation are described.