Palladium catalyzed thiol cross-coupling of cystein derivatives with aryl and alkenyl halides

Palladium catalyzed cystein thiol cross-coupling reactions with aryl and vinyl halides have been investigated: Pd2dba3-CHCl3 and dppf are the key choice in these reactions. The role of the base in these reactions was also questioned: it has been shown that base can be replaced by an HX-scavenger such as propylene oxide.