Synthesis and enantiomeric resolution of ferrocenyl(alkyl)azoles

Ferrocenyl(alkyl)azoles were synthesized in high yields by interaction of α-ferrocenylcarbinoles with azoles in aqueous–organic in the presence of HBF4 or by interaction of α-ferrocenylcarbinoles with N,N′-carbonyldiimidazole, N,N′-thionyldiimidazole, N,N′-thionyldibenzimidazole in boiling dichloromethane. The resulting enantiomers of ferrocenyl(alkyl)azoles and some carbinoles were separated using HPLC on silica bonded chiral stationary phases based on cyclodextrins and modified cellulose.