Synthesis, crystal structures and in vitro antitumor activities of some arylantimony derivatives of analogues of demethylcantharimide

A series of novel arylantimony derivatives of analogues of demethylcantharimide with the formulae ArnSbL(5−n) and ArnSbL′(5−n)(LH=N-hydroxy-demethyldehydrogencantharimide, L′H=N-hydroxy-demethylcantharimide, n=3, 4; ArC6H5, 4-CH3C6H4, 3-CH3C6H4, 2-CH3C6H4, 4-ClC6H4, 4-FC6H4) were synthesized and characterized by elemental analysis, IR, 1H NMR and mass spectroscopy. The crystal structures of (C6H5)4SbL, (4-CH3C6H4)3SbL2 and (3-CH3C6H4)3SbL′2 were determined by X-ray diffraction. The in vitro antitumor activities of all compounds against six cancer cells are reported.