One-pot Pd-catalyzed hydrostannation/Stille reaction with acid chlorides as the electrophiles

A one-pot hydrostannation/Stille coupling sequence amenable to the employment of acid chloride electrophiles has been developed. In this protocol, palladium mediated alkyne hydrostannations using Me3SnF/PMHS as an in situ trimethyltin hydride source are followed by the addition of the acid chloride to afford a variety of α,β-unsaturated ketones in a single pot.