Title of article :
Study on DNA-binding properties and cytotoxicity in L1210 of La(III) complex with PMBP-isonicotinoyl hydrazone
Author/Authors :
Zhengyin Yang، نويسنده , , Bao-dui Wang، نويسنده , , Yanhua Li، نويسنده ,
Issue Information :
دوفصلنامه با شماره پیاپی سال 2006
Abstract :
La(III) complex with 1-phenyl-3-methyl-5-hydroxy-4-pyrazolyl phenyl ketone (PMBP)-isonicotinoyl hydrazone (La-complex) was synthesized in the work. The crystal of the La-complex was determined by X-ray diffraction analyses, the crystal of the complex is rhomb, space group R3 with Z = 6, the coordination polyhedron of the complex is a tricapped triprism configuration with the nine-coordinate atoms, and the La-complex molecule looks like a helix structure according to its spacefill picture. Besides, it has been discovered that the La-complex possesses cytotoxic activities, and inhibitory rate for Leukemia cells (L1210) is 87.1%. The interaction of the La-complex with DNA was investigated by absorption spectrum, fluorescence, CD spectrum and viscosity measurements. The DNA-binding constant for the La-complex is (4.30 ± 0.14) × 106 M−1.
Keywords :
La-complex , PMBP-isonicotinoyl hydrazone , DNA-binding , Cytotoxic activities
Journal title :
Journal of Organometallic Chemistry
Journal title :
Journal of Organometallic Chemistry