Author/Authors :
Shah، نويسنده , , Vibhakar J. and Cerpa، نويسنده , , Robert R. Kuntz، نويسنده , , Jr.، نويسنده , , Irwin D. and Kenyon، نويسنده , , George L.، نويسنده ,
Abstract :
The first solid-phase synthesis of novel peptide-derived enantiospecific nucleic acid analogs (PDNAs), employing all three stereoisomers of 4-(N9-adeninyl)-2-amino(t-boc)-butyric acid as ADNA (amino acid-derived nucleoside analogs) monomers has been described. The preliminary melting temperature (Tm) data obtained by hybridization experiments demonstrated that these PDNAs can anneal to their complementary nucleic acid strand dT10.
