Title of article
Dinuclear macrocyclic polyamine zinc(II) complexes linked with flexible spacers: Synthesis, characterization, and DNA cleavage
Author/Authors
Peng، نويسنده , , Wei and Liu، نويسنده , , Pei-Yan and Jiang، نويسنده , , Ning and Lin، نويسنده , , Hong-Hui and Zhang، نويسنده , , Guo-Lin and Liu، نويسنده , , Yi and Yu، نويسنده , , Xiao-Qi، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
12
From page
374
To page
385
Abstract
Dinuclear macrocyclic polyamine zinc(II) complexes, which have two cyclen groups linked by flexible spacers, have been synthesized as DNA cleavage agents. The structures of these new dinuclear complexes are consistent with the data obtained from elemental analysis, MS and 1H NMR spectroscopy. The catalytic activity of these dinuclear complexes on DNA cleavage was studied. The results showed that the dinuclear zinc(II) complexes can catalyze the cleavage of supercoiled DNA (pUC 19 plasmid DNA) (Form I) under physiological conditions to produce selectively nicked DNA (Form II).
Keywords
cleavage , pUC 19 DNA , 4 , 7 , 10-Tetraazacyclododecane (cyclen) , Dinuclear complexes , 1 , Macrocyclic polyamine
Journal title
Bioorganic Chemistry: an International Journal
Serial Year
2005
Journal title
Bioorganic Chemistry: an International Journal
Record number
1385826
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